BH4 domain of Bcl-2 as a novel target for cancer therapy.
Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC4882289 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
BH4 domain of Bcl-2 as a novel target for cancer therapy.
Liu Zhiqing Z Wild Christopher C Ding Ye Y Ye Na N Chen Haiying H Wold Eric A EA Zhou Jia J
Drug discovery today 20151126 6
Overexpression of B cell lymphoma 2 (Bcl-2) proteins is associated with therapy resistance in various human cancers. Traditional approaches target the Bcl-2 homology (BH)3 domain of Bcl-2; however, the BH4 domain represents a superior therapeutic target in light of its unique structure and crucial involvement in many cellular functions. In this critical review, we focus on the structural and functional basis of targeting the BH4 domain of Bcl-2, and highlight the recent advances in drug discover ...[more]
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