Interplay between the kinin B1 receptor and inducible nitric oxide synthase in insulin resistance.

ABSTRACT:

Background and purpose

Kinins are vasoactive and pro-inflammatory peptides whose biological effects are mediated by two GPCRs, named B1 and B2 receptors. While the B2 receptor plays a protective role in the cardiovascular system via the activation of endothelial NOS, the B1 receptor is associated with vascular inflammation, insulin resistance and diabetic complications. Because the B1 receptor is a potent activator of the inducible form of NOS (iNOS), this study has addressed the role of iNOS in the deleterious effects of B1 receptors in insulin resistance.

Experimental approach

Male Sprague-Dawley rats (50-75 g) had free access to a drinking solution containing 10% d-glucose or tap water (control) for 9 weeks. During the last week, a selective iNOS inhibitor (1400W, 1 mg·kg

SUBMITTER: Haddad Y 

PROVIDER: S-EPMC4882489 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature