Ontology highlight
ABSTRACT:
SUBMITTER: Lazarczyk MJ
PROVIDER: S-EPMC4882527 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Lazarczyk Maciej J MJ Kemmler Julia E JE Eyford Brett A BA Short Jennifer A JA Varghese Merina M Sowa Allison A Dickstein Daniel R DR Yuk Frank J FJ Puri Rishi R Biron Kaan E KE Leist Marcel M Jefferies Wilfred A WA Dickstein Dara L DL
Scientific reports 20160527
Major histocompatibility complex class I (MHCI) proteins have been implicated in neuronal function through the modulation of neuritogenesis, synaptogenesis, synaptic plasticity, and memory consolidation during development. However, the involvement of MHCI in the aged brain is unclear. Here we demonstrate that MHCI deficiency results in significant dendritic atrophy along with an increase in thin dendritic spines and a reduction in stubby spines in the hippocampus of aged (12 month old) mice. Ult ...[more]