Efficacy of Indian polyvalent snake antivenoms against Sri Lankan snake venoms: lethality studies or clinically focussed in vitro studies.
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ABSTRACT:
SUBMITTER: Maduwage K
PROVIDER: S-EPMC4882578 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Efficacy of Indian polyvalent snake antivenoms against Sri Lankan snake venoms: lethality studies or clinically focussed in vitro studies.
Maduwage Kalana K Silva Anjana A O'Leary Margaret A MA Hodgson Wayne C WC Isbister Geoffrey K GK
Scientific reports 20160527
In vitro antivenom efficacy studies were compared to rodent lethality studies to test two Indian snake antivenoms (VINS and BHARAT) against four Sri Lankan snakes. In vitro efficacy was tested at venom concentrations consistent with human envenoming. Efficacy was compared statistically for one batch from each manufacturer where multiple vials were available. In binding studies EC50 for all VINS antivenoms were less than BHARAT for D. russelii [553 μg/mL vs. 1371 μg/mL;p = 0.016), but were greate ...[more]
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