Ontology highlight
ABSTRACT:
SUBMITTER: Fotuhi Siahpirani A
PROVIDER: S-EPMC4882777 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Fotuhi Siahpirani Alireza A Ay Ferhat F Roy Sushmita S
Genome biology 20160527 1
Chromosome conformation capture methods are being increasingly used to study three-dimensional genome architecture in multiple cell types and species. An important challenge is to examine changes in three-dimensional architecture across cell types and species. We present Arboretum-Hi-C, a multi-task spectral clustering method, to identify common and context-specific aspects of genome architecture. Compared to standard clustering, Arboretum-Hi-C produced more biologically consistent patterns of c ...[more]