Ontology highlight
ABSTRACT:
SUBMITTER: Tagde A
PROVIDER: S-EPMC4882805 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Tagde Ashujit A Rajabi Hasan H Bouillez Audrey A Alam Maroof M Gali Reddy R Bailey Shannon S Tai Yu-Tzu YT Hideshima Teru T Anderson Kenneth K Avigan David D Kufe Donald D
Blood 20160223 21
Multiple myeloma (MM) cell lines and primary tumor cells are addicted to the MYC oncoprotein for survival. Little is known, however, about how MYC expression is upregulated in MM cells. The mucin 1 C-terminal subunit (MUC1-C) is an oncogenic transmembrane protein that is aberrantly expressed in MM cell lines and primary tumor samples. The present studies demonstrate that targeting MUC1-C with silencing by clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein ...[more]