ARID1A and TERT promoter mutations in dedifferentiated meningioma.

ABSTRACT: Unlike patients with World Health Organization (WHO) grade I meningiomas, which are considered benign, patients with WHO grade III meningiomas have very high mortality rates. The principles underlying tumor progression in meningioma are largely unknown, yet a detailed understanding of these mechanisms will be required for effective management of patients with these high grade lethal tumors. We present a case of an intraventricular meningioma that at first presentation displayed remarkable morphologic heterogeneity-composed of distinct regions independently fulfilling histopathologic criteria for WHO grade I, II, and III designations. The lowest grade regions had classic meningothelial features, while the highest grade regions were markedly dedifferentiated. Whereas progression in meningiom

SUBMITTER: Abedalthagafi MS 

PROVIDER: S-EPMC4882906 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature