Ontology highlight
ABSTRACT:
SUBMITTER: Patti T
PROVIDER: S-EPMC4883710 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Patti Tamara T Bembi Bruno B Cristin Piero P Mazzarol Flavia F Secco Erika E Pappalardo Carla C Musetti Rita R Martinuzzi Maurizio M Versolatto Serena S Cariati Roberta R Dardis Andrea A Marchetti Stefano S
Rice (New York, N.Y.) 20121206 1
<h4>Background</h4>The deficiency of human acid beta-glucosidase (hGCase) causes Gaucher disease, a rare genetically-inherited disorder currently treated by enzyme replacement therapy using recombinant CHO-derived GCase. In an attempt to provide an alternative and more efficient production system, a chimeric cDNA coding for hGCase operatively linked to the signal peptide of rice glutelin 4 (GluB4) was put under the control of the GluB4 endosperm-specific promoter and inserted into the genome of ...[more]