Ontology highlight
ABSTRACT:
SUBMITTER: Kumar Vr S
PROVIDER: S-EPMC4884104 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Kumar Vr Santhosh S Darisipudi Murthy N MN Steiger Stefanie S Devarapu Satish Kumar SK Tato Maia M Kukarni Onkar P OP Mulay Shrikant R SR Thomasova Dana D Popper Bastian B Demleitner Jana J Zuchtriegel Gabriele G Reichel Christoph C Cohen Clemens D CD Lindenmeyer Maja T MT Liapis Helen H Moll Solange S Reid Emma E Stitt Alan W AW Schott Brigitte B Gruner Sabine S Haap Wolfgang W Ebeling Martin M Hartmann Guido G Anders Hans-Joachim HJ
Journal of the American Society of Nephrology : JASN 20151113 6
Endothelial dysfunction is a central pathomechanism in diabetes-associated complications. We hypothesized a pathogenic role in this dysfunction of cathepsin S (Cat-S), a cysteine protease that degrades elastic fibers and activates the protease-activated receptor-2 (PAR2) on endothelial cells. We found that injection of mice with recombinant Cat-S induced albuminuria and glomerular endothelial cell injury in a PAR2-dependent manner. In vivo microscopy confirmed a role for intrinsic Cat-S/PAR2 in ...[more]