Ontology highlight
ABSTRACT:
SUBMITTER: Pietras EM
PROVIDER: S-EPMC4884136 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Pietras Eric M EM Mirantes-Barbeito Cristina C Fong Sarah S Loeffler Dirk D Kovtonyuk Larisa V LV Zhang SiYi S Lakshminarasimhan Ranjani R Chin Chih Peng CP Techner José-Marc JM Will Britta B Nerlov Claus C Steidl Ulrich U Manz Markus G MG Schroeder Timm T Passegué Emmanuelle E
Nature cell biology 20160425 6
Haematopoietic stem cells (HSCs) maintain lifelong blood production and increase blood cell numbers in response to chronic and acute injury. However, the mechanism(s) by which inflammatory insults are communicated to HSCs and their consequences for HSC activity remain largely unknown. Here, we demonstrate that interleukin-1 (IL-1), which functions as a key pro-inflammatory 'emergency' signal, directly accelerates cell division and myeloid differentiation of HSCs through precocious activation of ...[more]