Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences.
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ABSTRACT:
SUBMITTER: Poznik GD
PROVIDER: S-EPMC4884158 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences.
Poznik G David GD Xue Yali Y Mendez Fernando L FL Willems Thomas F TF Massaia Andrea A Wilson Sayres Melissa A MA Ayub Qasim Q McCarthy Shane A SA Narechania Apurva A Kashin Seva S Chen Yuan Y Banerjee Ruby R Rodriguez-Flores Juan L JL Cerezo Maria M Shao Haojing H Gymrek Melissa M Malhotra Ankit A Louzada Sandra S Desalle Rob R Ritchie Graham R S GR Cerveira Eliza E Fitzgerald Tomas W TW Garrison Erik E Marcketta Anthony A Mittelman David D Romanovitch Mallory M Zhang Chengsheng C Zheng-Bradley Xiangqun X Abecasis Gonçalo R GR McCarroll Steven A SA Flicek Paul P Underhill Peter A PA Coin Lachlan L Zerbino Daniel R DR Yang Fengtang F Lee Charles C Clarke Laura L Auton Adam A Erlich Yaniv Y Handsaker Robert E RE Bustamante Carlos D CD Tyler-Smith Chris C
Nature genetics 20160425 6
We report the sequences of 1,244 human Y chromosomes randomly ascertained from 26 worldwide populations by the 1000 Genomes Project. We discovered more than 65,000 variants, including single-nucleotide variants, multiple-nucleotide variants, insertions and deletions, short tandem repeats, and copy number variants. Of these, copy number variants contribute the greatest predicted functional impact. We constructed a calibrated phylogenetic tree on the basis of binary single-nucleotide variants and ...[more]
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