Ontology highlight
ABSTRACT:
SUBMITTER: Lee SY
PROVIDER: S-EPMC4884964 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Lee Su Yeon SY Jeon Hyun Min HM Ju Min Kyung MK Jeong Eui Kyong EK Kim Cho Hee CH Park Hye Gyeong HG Han Song Iy SI Kang Ho Sung HS
Oncotarget 20160201 7
Most cancer cells depend on enhanced glucose and glutamine (Gln) metabolism for growth and survival. Oncogenic metabolism provides biosynthetic precursors for nucleotides, lipids, and amino acids; however, its specific roles in tumor progression are largely unknown. We previously showed that distal-less homeobox-2 (Dlx-2), a homeodomain transcription factor involved in embryonic and tumor development, induces glycolytic switch and epithelial-mesenchymal transition (EMT) by inducing Snail express ...[more]