Ontology highlight
ABSTRACT:
SUBMITTER: Law BY
PROVIDER: S-EPMC4884978 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Law Betty Yuen Kwan BY Mok Simon Wing Fai SW Chan Wai Kit WK Xu Su Wei SW Wu An Guo AG Yao Xiao Jun XJ Wang Jing Rong JR Liu Liang L Wong Vincent Kam Wai VK
Oncotarget 20160201 7
Drug resistance hinder most cancer chemotherapies and leads to disease recurrence and poor survival of patients. Resistance of cancer cells towards apoptosis is the major cause of these symptomatic behaviours. Here, we showed that isoquinoline alkaloids, including liensinine, isoliensinine, dauricine, cepharanthine and hernandezine, putatively induce cytotoxicity against a repertoire of cancer cell lines (HeLa, A549, MCF-7, PC3, HepG2, Hep3B and H1299). Proven by the use of apoptosis-resistant c ...[more]