Ontology highlight
ABSTRACT:
SUBMITTER: Stefanovic M
PROVIDER: S-EPMC4884990 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Stefanovic Milica M Tutusaus Anna A Martinez-Nieto Guillermo A GA Bárcena Cristina C de Gregorio Estefania E Moutinho Catia C Barbero-Camps Elisabet E Villanueva Alberto A Colell Anna A Marí Montserrat M García-Ruiz Carmen C Fernandez-Checa Jose C JC Morales Albert A
Oncotarget 20160201 7
Evasive mechanisms triggered by the tyrosine kinase inhibitor sorafenib reduce its efficacy in hepatocellular carcinoma (HCC) treatment. Drug-resistant cancer cells frequently exhibit sphingolipid dysregulation, reducing chemotherapeutic cytotoxicity via the induction of ceramide-degrading enzymes. However, the role of ceramide in sorafenib therapy and resistance in HCC has not been clearly established. Our data reveals that ceramide-modifying enzymes, particularly glucosylceramide synthase (GCS ...[more]