Ontology highlight
ABSTRACT:
SUBMITTER: Norvaisas P
PROVIDER: S-EPMC4885542 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Norvaisas Povilas P Chan Diana D Yokoi Kenji K Dave Bhuvanesh B Ziemys Arturas A
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20160101 1
NSAIDs have been observed to have cancer-preventive properties, but the actual mechanism is elusive. We hypothesize that NSAIDs might have an effect through common pathways and targets of anticancer drugs by exploiting promiscuities of anticancer drug targets. Here, we have explored NSAIDs by their structural and pharmacophoric similarities with small anticancer molecules. In-silico analyses have shown a strong similarity between NSAIDs and protein kinase (PK) inhibitors. The calculated affiniti ...[more]