Ontology highlight
ABSTRACT:
SUBMITTER: Kalchschmidt JS
PROVIDER: S-EPMC4886369 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Kalchschmidt Jens S JS Bashford-Rogers Rachael R Paschos Kostas K Gillman Adam C T AC Styles Christine T CT Kellam Paul P Allday Martin J MJ
The Journal of experimental medicine 20160523 6
Activation-induced cytidine deaminase (AID), the enzyme responsible for induction of sequence variation in immunoglobulins (Igs) during the process of somatic hypermutation (SHM) and also Ig class switching, can have a potent mutator phenotype in the development of lymphoma. Using various Epstein-Barr virus (EBV) recombinants, we provide definitive evidence that the viral nuclear protein EBNA3C is essential in EBV-infected primary B cells for the induction of AID mRNA and protein. Using lymphobl ...[more]