Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function.
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ABSTRACT:
SUBMITTER: Drosatos K
PROVIDER: S-EPMC4886555 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function.
Drosatos Konstantinos K Pollak Nina M NM Pol Christine J CJ Ntziachristos Panagiotis P Willecke Florian F Valenti Mesele-Christina MC Trent Chad M CM Hu Yunying Y Guo Shaodong S Aifantis Iannis I Goldberg Ira J IJ
Circulation research 20151116 2
<h4>Rationale</h4>Fatty acid oxidation is transcriptionally regulated by peroxisome proliferator-activated receptor (PPAR)α and under normal conditions accounts for 70% of cardiac ATP content. Reduced Ppara expression during sepsis and heart failure leads to reduced fatty acid oxidation and myocardial energy deficiency. Many of the transcriptional regulators of Ppara are unknown.<h4>Objective</h4>To determine the role of Krüppel-like factor 5 (KLF5) in transcriptional regulation of Ppara.<h4>Met ...[more]
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