The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation.
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ABSTRACT:
SUBMITTER: Molteni M
PROVIDER: S-EPMC4887650 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation.
Molteni Monica M Gemma Sabrina S Rossetti Carlo C
Mediators of inflammation 20160518
Toll-like receptor 4 (TLR4) belongs to the family of pattern recognition receptors (PRRs). They are highly conserved receptors that recognize conserved pathogen-associated molecular patterns (PAMPs), thus representing the first line of defense against infections. TLR4 has been long recognized as the sensing receptor for gram-negative lipopolysaccharide (LPS). In addition, it also binds endogenous molecules produced as a result of tissue injury. Hence, TLR4 represents a key receptor on which both ...[more]
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