Ontology highlight
ABSTRACT:
SUBMITTER: Tripathi A
PROVIDER: S-EPMC4888066 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Tripathi Abhishek A Drake Charles G CG Harshman Lauren C LC
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20141201 6
Programmed cell death-1 (PD-1) is a recognized immune checkpoint. It is frequently upregulated on the T cells that infiltrate tumors, providing an inhibitory signal, which may facilitate immune escape. Blocking antibodies have been developed to interrupt the interaction of PD-1 with its ligands PD-L1/PD-L2, with the goal of increasing the host antitumor immune response. Initial results have been encouraging, with durable responses in both treatment-naive and pretreated patients, along with an ac ...[more]