Ontology highlight
ABSTRACT:
SUBMITTER: Yang CS
PROVIDER: S-EPMC4888081 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Yang Chao-Shun CS Chang Kung-Yen KY Dang Jason J Rana Tariq M TM
Scientific reports 20160601
The polycomb repressive complex 1 (PRC1) is a multi-subunit complex that plays critical roles in the epigenetic modulation of gene expression. Here, we show that the PRC1 component polycomb group ring finger 6 (Pcgf6) is required to maintain embryonic stem cell (ESC) identity. In contrast to canonical PRC1, Pcgf6 acts as a positive regulator of transcription and binds predominantly to promoters bearing active chromatin marks. Pcgf6 is expressed at high levels in ESCs, and knockdown reduces the e ...[more]