Ontology highlight
ABSTRACT:
SUBMITTER: Weber MR
PROVIDER: S-EPMC4888909 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Weber Martin R MR Zuka Masahiko M Lorger Mihaela M Tschan Mario M Torbett Bruce E BE Zijlstra Andries A Quigley James P JP Staflin Karin K Eliceiri Brian P BP Krueger Joseph S JS Marchese Patrizia P Ruggeri Zaverio M ZM Felding Brunhilde H BH
Thrombosis research 20160401
Metastasis is the main cause of death in cancer patients, and understanding mechanisms that control tumor cell dissemination may lead to improved therapy. Tumor cell adhesion receptors contribute to cancer spreading. We noted earlier that tumor cells can expressing the adhesion receptor integrin αvβ3 in distinct states of activation, and found that cells which metastasize from the blood stream express it in a constitutively high affinity form. Here, we analyzed steps of the metastatic cascade in ...[more]