Ontology highlight
ABSTRACT:
SUBMITTER: Merkwirth C
PROVIDER: S-EPMC4889222 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Merkwirth Carsten C Jovaisaite Virginija V Durieux Jenni J Matilainen Olli O Jordan Sabine D SD Quiros Pedro M PM Steffen Kristan K KK Williams Evan G EG Mouchiroud Laurent L Tronnes Sarah U SU Murillo Virginia V Wolff Suzanne C SC Shaw Reuben J RJ Auwerx Johan J Dillin Andrew A
Cell 20160428 5
Across eukaryotic species, mild mitochondrial stress can have beneficial effects on the lifespan of organisms. Mitochondrial dysfunction activates an unfolded protein response (UPR(mt)), a stress signaling mechanism designed to ensure mitochondrial homeostasis. Perturbation of mitochondria during larval development in C. elegans not only delays aging but also maintains UPR(mt) signaling, suggesting an epigenetic mechanism that modulates both longevity and mitochondrial proteostasis throughout li ...[more]