Ontology highlight
ABSTRACT:
SUBMITTER: Villalta SA
PROVIDER: S-EPMC4889432 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Villalta S Armando SA Rosenthal Wendy W Martinez Leonel L Kaur Amanjot A Sparwasser Tim T Tidball James G JG Margeta Marta M Spencer Melissa J MJ Bluestone Jeffrey A JA
Science translational medicine 20141001 258
We examined the hypothesis that regulatory T cells (Tregs) modulate muscle injury and inflammation in the mdx mouse model of Duchenne muscular dystrophy (DMD). Although Tregs were largely absent in the muscle of wild-type mice and normal human muscle, they were present in necrotic lesions, displayed an activated phenotype, and showed increased expression of interleukin-10 (IL-10) in dystrophic muscle from mdx mice. Depletion of Tregs exacerbated muscle injury and the severity of muscle inflammat ...[more]