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Regulatory T cells control diabetes without compromising acute anti-viral defense.


ABSTRACT: While previous reports have demonstrated the efficacy of regulatory T cell therapy in the prevention of diabetes, systemic immunocompromise and Treg instability remain key safety concerns. Here we examined the influence of induced Treg (iTreg) cell therapy on anti-viral host defense and autoimmune T cell responses during acute viral infection in a murine model of autoimmune diabetes. Protective transfers of iTregs maintained IL-10 expression, expanded in vivo and controlled diabetes, despite losing FoxP3 expression. Adoptive transfer of iTregs affected neither the primary anti-viral CD8 T cell response nor viral clearance, although a significant and sustained suppression of CD4 T cell responses was observed. Following acute viral clearance, iTregs transferred early suppressed both CD4 and CD8 T cell responses, which resulted in the reversion of diabetes. These observations indicate that iTregs suppress local autoimmune processes while preserving the immunocompetent host's ability to combat acute viral infection.

SUBMITTER: Jones CB 

PROVIDER: S-EPMC4889438 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Regulatory T cells control diabetes without compromising acute anti-viral defense.

Jones Carmen Baca CB   Pagni Philippe P PP   Fousteri Georgia G   Sachithanantham Sowbarnika S   Dave Amy A   Rodriguez-Calvo Teresa T   Miller Jacqueline J   von Herrath Matthias M  

Clinical immunology (Orlando, Fla.) 20140522 2


While previous reports have demonstrated the efficacy of regulatory T cell therapy in the prevention of diabetes, systemic immunocompromise and Treg instability remain key safety concerns. Here we examined the influence of induced Treg (iTreg) cell therapy on anti-viral host defense and autoimmune T cell responses during acute viral infection in a murine model of autoimmune diabetes. Protective transfers of iTregs maintained IL-10 expression, expanded in vivo and controlled diabetes, despite los  ...[more]

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