Ontology highlight
ABSTRACT:
SUBMITTER: Jones CB
PROVIDER: S-EPMC4889438 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Jones Carmen Baca CB Pagni Philippe P PP Fousteri Georgia G Sachithanantham Sowbarnika S Dave Amy A Rodriguez-Calvo Teresa T Miller Jacqueline J von Herrath Matthias M
Clinical immunology (Orlando, Fla.) 20140522 2
While previous reports have demonstrated the efficacy of regulatory T cell therapy in the prevention of diabetes, systemic immunocompromise and Treg instability remain key safety concerns. Here we examined the influence of induced Treg (iTreg) cell therapy on anti-viral host defense and autoimmune T cell responses during acute viral infection in a murine model of autoimmune diabetes. Protective transfers of iTregs maintained IL-10 expression, expanded in vivo and controlled diabetes, despite los ...[more]