Ontology highlight
ABSTRACT:
SUBMITTER: Lu H
PROVIDER: S-EPMC4889462 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Lu Hezhe H Liu Shujing S Zhang Gao G Kwong Lawrence N LN Zhu Yueyao Y Miller John P JP Hu Yi Y Zhong Wenqun W Zeng Jingwen J Wu Lawrence L Krepler Clemens C Sproesser Katrin K Xiao Min M Xu Wei W Karakousis Giorgos C GC Schuchter Lynn M LM Field Jeffery J Zhang Paul J PJ Herlyn Meenhard M Xu Xiaowei X Guo Wei W
Cell reports 20160519 9
Melanoma patients with oncogenic BRAF(V600E) mutation have poor prognoses. While the role of BRAF(V600E) in tumorigenesis is well established, its involvement in metastasis that is clinically observed in melanoma patients remains a topic of debate. Here, we show that BRAF(V600E) melanoma cells have extensive invasion activity as assayed by the generation of F-actin and cortactin foci that mediate membrane protrusion, and degradation of the extracellular matrix (ECM). Inhibition of BRAF(V600E) bl ...[more]