Cellular distribution of injected PLGA-nanoparticles in the liver.
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ABSTRACT:
SUBMITTER: Park JK
PROVIDER: S-EPMC4889500 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Cellular distribution of injected PLGA-nanoparticles in the liver.
Park Jin-Kyu JK Utsumi Teruo T Seo Young-Eun YE Deng Yang Y Satoh Ayano A Saltzman William Mark WM Iwakiri Yasuko Y
Nanomedicine : nanotechnology, biology, and medicine 20160304 5
The cellular fate of nanoparticles in the liver is not fully understood. Because the effectiveness and safety of nanoparticles in liver therapy depends on targeting nanoparticles to the right cell populations, this study aimed to determine a relative distribution of PLGA-nanoparticles (sizes 271±1.4 nm) among liver cells in vivo. We found that Kupffer cells were the major cells that took up nanoparticles, followed by liver sinusoidal endothelial cells and hepatic stellate cells. Nanoparticles we ...[more]
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