Ontology highlight
ABSTRACT:
SUBMITTER: Anderson NM
PROVIDER: S-EPMC4889531 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Anderson N M NM Li D D Peng H L HL Laroche F J F FJ Mansour M R MR Gjini E E Aioub M M Helman D J DJ Roderick J E JE Cheng T T Harrold I I Samaha Y Y Meng L L Amsterdam A A Neuberg D S DS Denton T T TT Sanda T T Kelliher M A MA Singh A A Look A T AT Feng H H
Leukemia 20160215 6
Despite the pivotal role of MYC in the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and many other cancers, the mechanisms underlying MYC-mediated tumorigenesis remain inadequately understood. Here we utilized a well-characterized zebrafish model of Myc-induced T-ALL for genetic studies to identify novel genes contributing to disease onset. We found that heterozygous inactivation of a tricarboxylic acid (TCA) cycle enzyme, dihydrolipoamide S-succinyltransferase (Dlst), significant ...[more]