LncRNA MALAT1 exerts oncogenic functions in lung adenocarcinoma by targeting miR-204.
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ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC4889723 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
LncRNA MALAT1 exerts oncogenic functions in lung adenocarcinoma by targeting miR-204.
Li Jipeng J Wang Jianhua J Chen Yin Y Li Shanfeng S Jin Mingwei M Wang Huaying H Chen Zhe Z Yu Wanjun W
American journal of cancer research 20160501 5
Accumulating evidence indicates that the lncRNAs play a critical role in cancer progression and metastasis. In this study, we found that MALAT1 upregulation was associated with larger tumor size and lymph-node metastasis, and also correlated with shorter overall survival of lung adenocarcinoma patients. Furthermore, MALAT1 promotes EMT and metastasis of lung adenocarcinoma cells in vitro and in vivo. In particular, MALAT1 upregulated the expression of miR-204 target gene SLUG through competitive ...[more]
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