Ontology highlight
ABSTRACT:
SUBMITTER: Yasar S
PROVIDER: S-EPMC4890033 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Yasar Selcuk S Schimelman Jacob B JB Aksoyoglu M Alphan MA Steinmetz Nicole F NF French Roger H RH Parsegian V Adrian VA Podgornik Rudolf R
Scientific reports 20160602
Observed in the folds of guanine-rich oligonucleotides, non-canonical G-quadruplex structures are based on G-quartets formed by hydrogen bonding and cation-coordination of guanosines. In dilute 5'-guanosine monophosphate (GMP) solutions, G-quartets form by the self-assembly of four GMP nucleotides. We use x-ray diffraction to characterize the columnar liquid-crystalline mesophases in concentrated solutions of various model G-quadruplexes. We then probe the transitions between mesophases by varyi ...[more]