Ontology highlight
ABSTRACT:
SUBMITTER: Friedman AK
PROVIDER: S-EPMC4890180 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Friedman Allyson K AK Juarez Barbara B Ku Stacy M SM Zhang Hongxing H Calizo Rhodora C RC Walsh Jessica J JJ Chaudhury Dipesh D Zhang Song S Hawkins Angel A Dietz David M DM Murrough James W JW Ribadeneira Maria M Wong Erik H EH Neve Rachael L RL Han Ming-Hu MH
Nature communications 20160524
Less than half of patients suffering from major depressive disorder, a leading cause of disability worldwide, achieve remission with current antidepressants, making it imperative to develop more effective treatment. A new therapeutic direction is emerging from the increased understanding of natural resilience as an active stress-coping process. It is known that potassium (K(+)) channels in the ventral tegmental area (VTA) are an active mediator of resilience. However, no druggable targets have b ...[more]