Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Y
PROVIDER: S-EPMC4890318 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Yuan Yaxia Y Quizon Pamela M PM Sun Wei-Lun WL Yao Jianzhuang J Zhu Jun J Zhan Chang-Guo CG
Scientific reports 20160602
HIV-1 Tat plays an important role in HIV-associated neurocognitive disorders (HAND) by disrupting neurotransmission including dopamine uptake by human dopamine transporter (hDAT). Previous studies have demonstrated that HIV-1 Tat directly binds to hDAT and some amino-acid mutations that attenuate the hDAT-Tat binding also significantly decreased dopamine uptake activity of hDAT. This combined computational-experimental study demonstrates that histidine-547 (H547) of hDAT plays a crucial role in ...[more]