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Surgical Outcomes of Synchronous Multiple Primary Non-Small Cell Lung Cancers.


ABSTRACT: The prognostic indicators for synchronous multiple primary non-small cell lung cancer (NSCLC) vary across reports. In present study, the prognostic factors for the patients with synchronous multiple primary NSCLC were analyzed in a large cohort. A total of 285 patients with synchronous multiple primary NSCLC who underwent radical surgical resection and with complete follow-up information were included in this study. The Kaplan-Meier method were used for survival analysis, Cox proportional hazards regression models were used for risk factors evaluation. Among them, 94 (33.0%) patients had bilateral tumors and 51 (17.9%) had multiple (?3) tumors. The 5-year disease-free survival (DFS) and overall survival (OS) rate was 58.7% and 77.6%, respectively. Univariate analysis identified parameters conferring shorter OS including male gender, symptomatic disease, negative family history, large maximal tumor size, not all adenocarcinomas, advanced highest T stage, and lymph node involvement. Multivariate analysis showed that male gender (p?=?0.020), symptomatic disease (p?=?0.017), and lymph node involvement (p?

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC4890551 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Surgical Outcomes of Synchronous Multiple Primary Non-Small Cell Lung Cancers.

Zhang Zhirong Z   Gao Shugeng S   Mao Yousheng Y   Mu Juwei J   Xue Qi Q   Feng Xiaoli X   He Jie J  

Scientific reports 20160602


The prognostic indicators for synchronous multiple primary non-small cell lung cancer (NSCLC) vary across reports. In present study, the prognostic factors for the patients with synchronous multiple primary NSCLC were analyzed in a large cohort. A total of 285 patients with synchronous multiple primary NSCLC who underwent radical surgical resection and with complete follow-up information were included in this study. The Kaplan-Meier method were used for survival analysis, Cox proportional hazard  ...[more]

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