Ontology highlight
ABSTRACT:
SUBMITTER: Rivoire O
PROVIDER: S-EPMC4890866 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Rivoire Olivier O Reynolds Kimberly A KA Ranganathan Rama R
PLoS computational biology 20160602 6
The essential biological properties of proteins-folding, biochemical activities, and the capacity to adapt-arise from the global pattern of interactions between amino acid residues. The statistical coupling analysis (SCA) is an approach to defining this pattern that involves the study of amino acid coevolution in an ensemble of sequences comprising a protein family. This approach indicates a functional architecture within proteins in which the basic units are coupled networks of amino acids term ...[more]