Cold inducible RNA binding protein upregulation in pituitary corticotroph adenoma induces corticotroph cell proliferation via Erk signaling pathway.
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ABSTRACT:
SUBMITTER: Jian F
PROVIDER: S-EPMC4891034 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
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Cold inducible RNA binding protein upregulation in pituitary corticotroph adenoma induces corticotroph cell proliferation via Erk signaling pathway.
Jian Fangfang F Chen Yufan Y Ning Guang G Fu Wei W Tang Hao H Chen Xiao X Zhao Yao Y Zheng Lili L Pan Sijian S Wang Weiqing W Bian Liuguan L Sun Qingfang Q
Oncotarget 20160201 8
Cushing's disease is caused by pituitary corticotroph adenoma, and the pathogenesis of it has remained obscure. Here, we showed that cold inducible RNA binding protein (CIRP) was markedly elevated in corticotroph tumors. Forced overexpression of CIRP in murine AtT20 pituitary corticotroph cell line increased corticotroph precursor hormone proopiomelanocortin (POMC) transcription, ACTH secretion and cellular proliferation. In vivo, CIRP overexpression promotes murine corticotroph tumor growth and ...[more]
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