Multimorbidity and neuroimaging biomarkers among cognitively normal persons.
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ABSTRACT: Objective
To assess the cross-sectional association between multimorbidity and imaging biomarkers of brain pathology in the population-based Mayo Clinic Study of Aging (MCSA).Methods
The study consisted of 1,449 MCSA participants who were cognitively normal at the time of MRI. A subset of the participants also had (11)C-Pittsburgh compound B (n = 689) and (18)fluorodeoxyglucose (n = 688) PET scans available. Information on multimorbidity (defined as ?2 chronic conditions) in the 5 years prior to the first imaging study was captured from the medical record using ICD-9 codes for chronic conditions and the Rochester Epidemiology Project medical records linkage system. The cross-sectional association of multimorbidity and imaging biomarkers was examined using logistic and linear regression models.Results
Among 1,449 cognitively normal participants (mean age 79 years; 50.9% men), 85.4% had multimorbidity (?2 chronic conditions). Multimorbidity and severe multimorbidity (?4 chronic conditions) were associated with abnormal Alzheimer disease (AD) signature meta-region of interest (meta-ROI) (18)F-FDG hypometabolism (odds ratio [OR] 2.03; 95% confidence interval [CI] 1.10-3.77 and OR 2.22; 95% CI 1.18-4.16, respectively), and with abnormal AD signature MRI cortical thickness (OR 1.53; 95% CI 1.09-2.16 and OR 1.76; 95% CI 1.24-2.51, respectively), but was not associated with amyloid accumulation.Conclusions
Multimorbidity was associated with brain pathology through mechanisms independent of amyloid deposition and such neuronal injury and pathology was present before any symptomatic evidence of cognitive impairment. Longitudinal follow-up will provide insights into potential causal associations of multimorbidity with changes in brain pathology.
SUBMITTER: Vassilaki M
PROVIDER: S-EPMC4891208 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Multimorbidity and neuroimaging biomarkers among cognitively normal persons.
Vassilaki Maria M Aakre Jeremiah A JA Mielke Michelle M MM Geda Yonas E YE Kremers Walter K WK Alhurani Rabe E RE Machulda Mary M MM Knopman David S DS Petersen Ronald C RC Lowe Val J VJ Jack Clifford R CR Roberts Rosebud O RO
Neurology 20160413 22
<h4>Objective</h4>To assess the cross-sectional association between multimorbidity and imaging biomarkers of brain pathology in the population-based Mayo Clinic Study of Aging (MCSA).<h4>Methods</h4>The study consisted of 1,449 MCSA participants who were cognitively normal at the time of MRI. A subset of the participants also had (11)C-Pittsburgh compound B (n = 689) and (18)fluorodeoxyglucose (n = 688) PET scans available. Information on multimorbidity (defined as ≥2 chronic conditions) in the ...[more]
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