Ontology highlight
ABSTRACT:
SUBMITTER: Pathania R
PROVIDER: S-EPMC4891240 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Pathania Rajneesh R Ramachandran Sabarish S Mariappan Gurusamy G Thakur Priyanka P Shi Huidong H Choi Jeong-Hyeon JH Manicassamy Santhakumar S Kolhe Ravindra R Prasad Puttur D PD Sharma Suash S Lokeshwar Bal L BL Ganapathy Vadivel V Thangaraju Muthusamy M
Cancer research 20160405 11
Recently, impressive technical advancements have been made in the isolation and validation of mammary stem cells and cancer stem cells (CSC), but the signaling pathways that regulate stem cell self-renewal are largely unknown. Furthermore, CSCs are believed to contribute to chemo- and radioresistance. In this study, we used the MMTV-Neu-Tg mouse mammary tumor model to identify potential new strategies for eliminating CSCs. We found that both luminal progenitor and basal stem cells are susceptibl ...[more]