COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis.

ABSTRACT: Identifying mechanisms through which individual differences in reward learning emerge offers an opportunity to understand both a fundamental form of adaptive responding as well as etiological pathways through which aberrant reward learning may contribute to maladaptive behaviors and psychopathology. One candidate mechanism through which individual differences in reward learning may emerge is variability in dopaminergic reinforcement signaling. A common functional polymorphism within the catechol-O-methyl transferase gene (COMT; rs4680, Val(158) Met) has been linked to reward learning, where homozygosity for the Met allele (linked to heightened prefrontal dopamine function and decreased dopamine synthesis in the midbrain) has been associated with relatively increased reward learning. Here,

SUBMITTER: Corral-Frias NS 

PROVIDER: S-EPMC4891272 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature