Ontology highlight
ABSTRACT:
SUBMITTER: Wu G
PROVIDER: S-EPMC4891365 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Wu Gang G Hitchen Paul G PG Panico Maria M North Simon J SJ Barbouche Mohamed-Ridha MR Binet Daniel D Morris Howard R HR Dell Anne A Haslam Stuart M SM
Glycoconjugate journal 20151219 3
Glycans serve as important regulators of antibody activities and half-lives. IgE is the most heavily glycosylated antibody, but in comparison to other antibodies little is known about its glycan structure function relationships. We therefore describe the site specific IgE glycosylation from a patient with a novel hyper IgE syndrome linked to mutations in PGM3, which is an enzyme involved in synthesizing UDP-GlcNAc, a sugar donor widely required for glycosylation. A two-step method was developed ...[more]