Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC4891684 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Zhang Lin L Zhang Lixing L Li Hong H Ge Chao C Zhao Fangyu F Tian Hua H Chen Taoyang T Jiang Guoping G Xie Haiyang H Cui Ying Y Yao Ming M Li Jinjun J
Scientific reports 20160603
Although the chemotactic cytokine CXCL3 is thought to play an important role in tumor initiation and invasion, little is known about its function in hepatocellular carcinoma (HCC). In our previous study, we found that Ikaros inhibited CD133 expression via the MAPK pathway in HCC. Here, we showed that Ikaros may indirectly down-regulate CXCL3 expression in HCC cells, which leads to better outcomes in patients with CD133(+) cancer stem cell (CSC) populations. CD133 overexpression induced CXCL3 exp ...[more]