Ontology highlight
ABSTRACT:
SUBMITTER: Lobanov MY
PROVIDER: S-EPMC4891720 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Lobanov Michail Yu MY Klus Petr P Sokolovsky Igor V IV Tartaglia Gian Gaetano GG Galzitskaya Oxana V OV
Scientific reports 20160603
The biological function of multiple repetitions of single amino acids, or homo-repeats, is largely unknown, but their occurrence in proteins has been associated with more than 20 hereditary diseases. Analysing 122 bacterial and eukaryotic genomes, we observed that the number of proteins containing homo-repeats is significantly larger than expected from theoretical estimates. Analysis of statistical significance indicates that the minimal size of homo-repeats varies with amino acid type and prote ...[more]