Ontology highlight
ABSTRACT:
SUBMITTER: Schrade A
PROVIDER: S-EPMC4891789 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Schrade Anja A Kyrönlahti Antti A Akinrinade Oyediran O Pihlajoki Marjut M Fischer Simon S Rodriguez Verena Martinez VM Otte Kerstin K Velagapudi Vidya V Toppari Jorma J Wilson David B DB Heikinheimo Markku M
Endocrinology 20160314 6
Conditional deletion of Gata4 in Sertoli cells (SCs) of adult mice has been shown to increase permeability of the blood-testis barrier (BTB) and disrupt spermatogenesis. To gain insight into the molecular underpinnings of these phenotypic abnormalities, we assessed the impact of Gata4 gene silencing in cell culture models. Microarray hybridization identified genes dysregulated by siRNA-mediated inhibition of Gata4 in TM4 cells, an immortalized mouse SC line. Differentially expressed genes were v ...[more]