VAV3 Gene Polymorphism Is Associated with Paget's Disease of Bone.
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ABSTRACT:
SUBMITTER: Usategui-Martin R
PROVIDER: S-EPMC4892207 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
VAV3 Gene Polymorphism Is Associated with Paget's Disease of Bone.
Usategui-Martín Ricardo R Calero-Paniagua Ismael I García-Aparicio Judith J Corral-Gudino Luis L Del Pino Montes Javier J González Sarmiento Rogelio R
Genetic testing and molecular biomarkers 20160512 6
<h4>Background and aims</h4>Paget's disease of bone (PDB) is a focal bone disorder affecting the skeleton segmentally. The disease affects osteoclasts which increase in size, number, and activity. One of the etiopathogenic hypotheses is that the disease is genetic. It has been reported that Rho GEF Vav3 is an essential factor in the regulation of osteoclast function, and alteration of the VAV3 gene could influence the development of the disease. The aim of our study was to perform an association ...[more]
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