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The nucleoside uridine isolated in the gas phase.

ABSTRACT: Herein we present the first experimental observation of the isolated nucleoside uridine, placed in the gas phase by laser ablation and characterized by Fourier transform (FT) microwave techniques. Free from the bulk effects of their native environments, anti/C2'-endo-g+ conformation has been revealed as the most stable form of uridine. Intramolecular hydrogen bonds involving uracil and ribose moieties have been found to play an important role in the stabilization of the nucleoside.

SUBMITTER: Pena I

PROVIDER: S-EPMC4892345 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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The nucleoside uridine isolated in the gas phase.

Peña Isabel I Cabezas Carlos C Alonso José L JL

Angewandte Chemie (International ed. in English) 20150212 10

Herein we present the first experimental observation of the isolated nucleoside uridine, placed in the gas phase by laser ablation and characterized by Fourier transform (FT) microwave techniques. Free from the bulk effects of their native environments, anti/C2'-endo-g+ conformation has been revealed as the most stable form of uridine. Intramolecular hydrogen bonds involving uracil and ribose moieties have been found to play an important role in the stabilization of the nucleoside. ...[more]

PMID: 25683559

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