Thyroid Hormones and Moderate Exposure to Perchlorate during Pregnancy in Women in Southern California.

ABSTRACT:

Background

Findings from national surveys suggest that everyone in the United States is exposed to perchlorate. At high doses, perchlorate, thiocyanate, and nitrate inhibit iodide uptake into the thyroid and decrease thyroid hormone production. Small changes in thyroid hormones during pregnancy, including changes within normal reference ranges, have been linked to cognitive function declines in the offspring.

Objectives

We evaluated the potential effects of low environmental exposures to perchlorate on thyroid function.

Methods

Serum thyroid hormones and anti-thyroid antibodies and urinary perchlorate, thiocyanate, nitrate, and iodide concentrations were measured in 1,880 pregnant women from San Diego County, California, during 2000-2003, a period when much of the are

SUBMITTER: Steinmaus C 

PROVIDER: S-EPMC4892913 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature