Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model.
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ABSTRACT:
SUBMITTER: Villasante A
PROVIDER: S-EPMC4893640 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model.
Villasante Aranzazu A Marturano-Kruik Alessandro A Ambati Srikanth R SR Liu Zen Z Godier-Furnemont Amandine A Parsa Hesam H Lee Benjamin W BW Moore Malcolm A S MA Vunjak-Novakovic Gordana G
Theranostics 20160521 8
There is a growing interest in the pivotal role of exosomes in cancer and in their use as biomarkers. However, despite the importance of the microenvironment for cancer initiation and progression, monolayer cultures of tumor cells still represent the main in vitro source of exosomes. As a result, their environmental regulation remains largely unknown. Here, we report a three-dimensional tumor model for studying exosomes, using Ewing's sarcoma type 1 as a clinically relevant example. The bioengin ...[more]
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