Ontology highlight
ABSTRACT:
SUBMITTER: Kuminek G
PROVIDER: S-EPMC4893792 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Kuminek G G Rodríguez-Hornedo N N Siedler S S Rocha H V A HV Cuffini S L SL Cardoso S G SG
Chemical communications (Cambridge, England) 20160404 34
Cocrystals of a weakly basic drug (nevirapine) with acidic coformers are shown to alter the solubility dependence on pH, and to exhibit a pHmax above which a less soluble cocrystal becomes more soluble than the drug. The cocrystal solubility advantage can be dialed up or down by solution pH. ...[more]