Dataset Information

Impact of female age and nulligravidity on fecundity in an older reproductive age cohort.

ABSTRACT:

Objective

To provide female age-related estimates of fecundity and incidence of infertility by history of prior pregnancy among women 30-44 years of age.

Design

Prospective, time-to-pregnancy cohort study.

Setting

Not applicable.

Patient(s)

Women, between 30 and 44 years of age, attempting to conceive for ≤3 months, and no known history of infertility, polycystic ovarian syndrome (PCOS), or endometriosis.

Intervention(s)

Not applicable.

Main outcome measure(s)

Fecundability and incidence of infertility.

Result(s)

Compared to women aged 30-31 years, fecundability was reduced by 14% in women 34-35 years of age (fecundability ratio [FR] 0.86, 95% confidence interval [CI] 0.68-1.08), 19% in women 36-37 years of age (FR 0.81, 95% CI 0.60-1.08, 30% in women 38-39 years of age (FR 0.70, 95% CI 0.48-1.01), 53% in women 40-41 years of age (FR 0.47, 95% CI 0.28-0.78), and 59% in women 42-44 years of age (FR 0.39, 95% CI 0.16-0.93). Fecundability did not differ between women aged 30-31 years and 32-33 years. In general, fecundability and cumulative probability of pregnancy was lower for women who had never had a prior pregnancy.

Conclusion(s)

Women experience a significant reduction in fecundity and increase in the probability of infertility in their late thirties. At any age >30 years, women who have never conceived have a lower probability of achieving a pregnancy.

Clinical trial registration number

NCT01028365.

SUBMITTER: Steiner AZ

PROVIDER: S-EPMC4893975 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Impact of female age and nulligravidity on fecundity in an older reproductive age cohort.

Steiner Anne Z AZ Jukic Anne Marie Z AM

Fertility and sterility 20160305 6

<h4>Objective</h4>To provide female age-related estimates of fecundity and incidence of infertility by history of prior pregnancy among women 30-44 years of age.<h4>Design</h4>Prospective, time-to-pregnancy cohort study.<h4>Setting</h4>Not applicable.<h4>Patient(s)</h4>Women, between 30 and 44 years of age, attempting to conceive for ≤3 months, and no known history of infertility, polycystic ovarian syndrome (PCOS), or endometriosis.<h4>Intervention(s)</h4>Not applicable.<h4>Main outcome measure ...[more]

PMID: 26953733

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Dataset Information

Impact of female age and nulligravidity on fecundity in an older reproductive age cohort.

Objective

Design

Setting

Patient(s)

Intervention(s)

Main outcome measure(s)

Result(s)

Conclusion(s)

Clinical trial registration number

Publications

Impact of female age and nulligravidity on fecundity in an older reproductive age cohort.

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