Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection.
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ABSTRACT:
SUBMITTER: Nichols CG
PROVIDER: S-EPMC4894346 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
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Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection.
Cardiac electrophysiology clinics 20160319 2
The subunit makeup of the family of adenosine triphosphate-sensitive potassium channel (KATP) channels is more complex and labile than thought. The growing association of Kir6.1 and SUR2 variants with specific cardiovascular electrical and contractile derangements and the clear association with Cantu syndrome establish the importance of appropriate activity in normal function of the heart and vasculature. Further studies of such patients will reveal new mutations in KATP subunits and perhaps in ...[more]
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