Ontology highlight
ABSTRACT:
SUBMITTER: Sadler B
PROVIDER: S-EPMC4894386 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Sadler Brooke B Haller Gabe G Agrawal Arpana A Culverhouse Rob R Bucholz Kathleen K Brooks Andy A Tischfield Jay J Johnson Eric O EO Edenberg Howard H Schuckit Marc M Saccone Nancy N Bierut Laura L Goate Alison A
Scientific reports 20140328
In the U.S.A., cocaine is the second most abused illicit drug. Variants within the CHRNB3-A6 gene cluster have been associated with cigarette consumption in several GWAS. These receptors represent intriguing candidates for the study of cocaine dependence because nicotinic receptors are thought to be involved in generalized addiction pathways. Using genotypic data from a GWAS of the Study of Addiction: Genetics and Environment (SAGE) dataset, we tested for association of CHRNB3-A6 SNPs with DSM-5 ...[more]