Ontology highlight
ABSTRACT:
SUBMITTER: Nair SK
PROVIDER: S-EPMC4894389 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Nair Smita K SK Tomaras Georgia D GD Sales Ana Paula AP Boczkowski David D Chan Cliburn C Plonk Kelly K Cai Yongting Y Dannull Jens J Kepler Thomas B TB Pruitt Scott K SK Weinhold Kent J KJ
Scientific reports 20140423
Emergence of drug-resistant strains of the pathogen Mycobacterium tuberculosis (Mtb) and the ineffectiveness of BCG in curtailing Mtb infection makes vaccine development for tuberculosis an important objective. Identifying immunogenic CD8+ T cell peptide epitopes is necessary for peptide-based vaccine strategies. We present a three-tiered strategy for identifying and validating immunogenic peptides: first, identify peptides that form stable complexes with class I MHC molecules; second, determine ...[more]